Computational Epidemiology Lab
Research
Our research spans dementia epidemiology, biomarker and surrogate endpoint evaluation, and quantitative approaches to assessing and strengthening the credibility of biomedical science.
Surrogate Evaluation
We develop and apply rigorous statistical frameworks for evaluating biomarkers—such as amyloid clearance—as surrogate endpoints for cognitive outcomes in Alzheimer's disease clinical trials. Our work examines whether treatment effects on intermediate biomarkers reliably predict effects on the clinical outcomes that matter to patients, and what standards of evidence should govern approval of new drug treatments.
Ackley SF, Flanders MD, Murchland A, Chen R, Wang J, Shah SJ, Huey ED, Glymour MM
Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias
Ackley SF, La Joie R, Caunca M, Mukherjee S, Choi SE, Trittschuh EH, Crane PK, Hayes-Larso…
Ackley SF, Gantenberg JR, Heston MB, La Joie R
Exploring Centiloid robustness: impact of sample size and image resolution on Centiloid conversion accuracy
Zhang J, Soleimani-Meigooni DN, Koeppe R, Ackley S, Schonhaut DR, Lin ZE, Maiti P, Yballa…
Ackley SF, Calmasini C, Bouteloup V, Hill-Jarrett TG, Swinnerton KN, Chêne G, Dufouil C, G…
Ackley SF, Wang J, Chen R, Power MC, Allen IE, Glymour MM
Hayes-Larson E, Ackley SF, Turney IC, La Joie R, Mayeda ER, Glymour MM, Alzheimer's Diseas…
Associations of amyloid burden, white matter hyperintensities, and hippocampal volume with cognitive trajectories in the 90+ Study
Wang J, Ackley SF, Woodworth DC, Sajjadi SA, Decarli CS, Fletcher EF, Glymour MM, Jiang L,…
Key questions for the evaluation of anti-amyloid immunotherapies for Alzheimer's disease
Liu KY, Villain N, Ayton S, Ackley SF, Planche V, Howard R, Thambisetty M
Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER,…
Ackley SF, Elahi F, Glymour MM
Ackley SF, Hayes-Larson E, Brenowitz WD, Swinnerton K, Mungas D, Fletcher E, Singh B, Whit…