Computational Epidemiology Lab

Publications

Selected publications. Google Scholar · MyNCBI

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31 papers

2026

3
Evaluation of amyloid change as a surrogate for cognitive decline: demonstration in individual-level data from the A4 study of solanezumab

Ackley SF, Flanders MD, Murchland A, Chen R, Wang J, Shah SJ, Huey ED, Glymour MM

Alzheimer's & Dementia: Translational Research & Clinical Interventions·2026
Surrogate EvaluationDementia EpidemiologyDrugs and Devices

Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias

Ackley SF, La Joie R, Caunca M, Mukherjee S, Choi SE, Trittschuh EH, Crane PK, Hayes-Larso…

Journal of Gerontology: Medical Sciences (accepted)·2026
Surrogate EvaluationDementia EpidemiologyMathematical Modeling

COVID-19 related brain MRI changes and anticipated long-term dementia risk: a front-door-criterion-inspired approach

Wang J, Ferguson EL, Chen R, Ackley SF, La Joie R, Kornak J, Kelly JD, Estiri H, Hsu J, Bl…

Annals of Epidemiology·2026
Dementia Epidemiology

2025

6
Trends in the distribution of P values in epidemiology journals: a statistical, P-curve, and simulation study

Ackley SF, Andrews RM, Seaman C, Flanders M, Chen R, Wang J, Lopes G, Sims KD, Buto P, Fer…

American Journal of Epidemiology·2025
Research Credibility & MetascienceMachine Learning and AIMathematical Modeling
Methods to crosswalk between cognitive test scores using data from the Alzheimer's Disease Neuroimaging Cohort

Ackley SF, Wang J, Chen R, Hill-Jarrett TG, Rojas-Saunero LP, Stokes A, Shah SJ, Glymour M…

Alzheimer's & Dementia·2025
Dementia EpidemiologyEvidence Triangulation
Evaluating the presence of a physiologic ceiling in amyloid trajectories: insights from the Sampled Iterative Local Approximation (SILA) algorithm and simulations

Ackley SF, Gantenberg JR, Heston MB, La Joie R

Alzheimer's & Dementia (AAIC abstract)·2025
Surrogate EvaluationMathematical Modeling

Early glycemic control and subsequent risk of incident dementia among new metformin users

Power MC, Madsen M, Bødkergaard K, Zimmerman SC, Ackley SF, Gilsanz P, Glymour MM, Henders…

The American Journal of Medicine·2025
Drug RepurposingDementia EpidemiologyDrugs and Devices

Exploring Centiloid robustness: impact of sample size and image resolution on Centiloid conversion accuracy

Zhang J, Soleimani-Meigooni DN, Koeppe R, Ackley S, Schonhaut DR, Lin ZE, Maiti P, Yballa…

Journal of Nuclear Medicine·2025
Surrogate Evaluation

Evaluation of polygenic risk scores for a possible genetic basis of the inverse association between cancer and cognitive decline

Graff RE, Chen DM, Swinnerton KN, Ackley SF, Ospina-Romero M, Zimmerman SC, Wang J, Buto P…

Alzheimer Disease & Associated Disorders·2025
Dementia EpidemiologyEvidence Triangulation

2024

6
Contribution of global amyloid-PET imaging for predicting future cognition in the MEMENTO cohort

Ackley SF, Calmasini C, Bouteloup V, Hill-Jarrett TG, Swinnerton KN, Chêne G, Dufouil C, G…

Neurology·2024
Surrogate EvaluationDementia EpidemiologyMachine Learning and AI
Estimated effects of amyloid reduction on cognitive change: a Bayesian update across a range of priors

Ackley SF, Wang J, Chen R, Power MC, Allen IE, Glymour MM

Alzheimer's & Dementia·2024
Surrogate EvaluationEvidence TriangulationDementia Epidemiology
Considerations for use of blood-based biomarkers in epidemiologic dementia research

Hayes-Larson E, Ackley SF, Turney IC, La Joie R, Mayeda ER, Glymour MM, Alzheimer's Diseas…

American Journal of Epidemiology·2024
Surrogate EvaluationDementia Epidemiology

Associations of amyloid burden, white matter hyperintensities, and hippocampal volume with cognitive trajectories in the 90+ Study

Wang J, Ackley SF, Woodworth DC, Sajjadi SA, Decarli CS, Fletcher EF, Glymour MM, Jiang L,…

Neurology·2024
Dementia EpidemiologySurrogate Evaluation

Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK Biobank participants

Buto PT, Wang J, La Joie R, Zimmerman SC, Glymour MM, Ackley SF, Hoffmann TJ, Yaffe K, Zek…

Alzheimer's & Dementia·2024
Dementia EpidemiologyEvidence Triangulation
Comparison of approaches to control for intracranial volume in research on the association of brain volumes with cognitive outcomes

Wang J, Hill-Jarrett T, Buto P, Pederson A, Sims KD, Zimmerman SC, DeVost MA, Ferguson E,…

Human Brain Mapping·2024
Dementia Epidemiology

2023

3
Metformin cessation and dementia incidence

Zimmerman SC, Ferguson EL, Choudhary V, Ranatunga DK, Oni-Orisan A, Hayes-Larson E, Folle…

JAMA Network Open·2023
Drug RepurposingDementia EpidemiologyDrugs and Devices
Discordance in chromosomal and self-reported sex in the UK Biobank: implications for transgender- and intersex-inclusive data collection

Ackley SF, Zimmerman SC, Flatt JD, Riley AR, Sevelius J, Duchowny KA

Proceedings of the National Academy of Sciences·2023
Research Credibility & Metascience

Key questions for the evaluation of anti-amyloid immunotherapies for Alzheimer's disease

Liu KY, Villain N, Ayton S, Ackley SF, Planche V, Howard R, Thambisetty M

Brain Communications·2023
Surrogate EvaluationDrugs and Devices

2022

2
Associations between handgrip strength and dementia risk, cognition, and neuroimaging outcomes in the UK Biobank cohort study

Duchowny KA, Ackley SF, Brenowitz WD, Wang J, Zimmerman SC, Caunca MR, Glymour MM

JAMA Network Open·2022
Dementia EpidemiologyEvidence Triangulation

Association of genetic variants linked to late-onset Alzheimer disease with cognitive test performance by midlife

Zimmerman SC, Brenowitz WD, Calmasini C, Ackley SF, Graff RE, Asiimwe SB, Staffaroni AM, H…

JAMA Network Open·2022
Dementia EpidemiologyEvidence Triangulation

2021

5
Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER,…

BMJ·2021
Surrogate EvaluationEvidence TriangulationDrugs and Devices
Instrumental variable meta-analysis of aggregated randomized drug trial data for evaluating proposed target mechanisms

Ackley SF, Elahi F, Glymour MM

BMJ·2021
Evidence TriangulationSurrogate Evaluation
Amyloid-PET imaging offers small improvements in predictions of future cognitive trajectories

Ackley SF, Hayes-Larson E, Brenowitz WD, Swinnerton K, Mungas D, Fletcher E, Singh B, Whit…

NeuroImage: Clinical·2021
Surrogate EvaluationDementia EpidemiologyMachine Learning and AI
Dynamical modeling as a tool for inferring causation

Ackley SF, Lessler J, Glymour MM

American Journal of Epidemiology·2021
Philosophy of ScienceMathematical ModelingResearch Credibility & Metascience

Genetic risk of Alzheimer's disease and sleep duration in non-demented elders

Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD

Annals of Neurology·2021
Dementia EpidemiologyEvidence Triangulation

2020

1
Assessing the utility of a smart thermometer and mobile application as a surveillance tool for influenza and influenza-like illness

Ackley SF, Pilewski S, Petrovic VS, Worden L, Murray E, Porco TC

Health Informatics Journal·2020
Drugs and Devices

2019

1
Multiple exposures, reinfection and risk of progression to active tuberculosis

Ackley SF, Lee RS, Worden L, Zwick E, Porco TC, Behr MA, Pepperell CS

Royal Society Open Science·2019
Mathematical Modeling

2018

1
Genotype-specific measles transmissibility: a branching process analysis

Ackley SF, Hacker JK, Enanoria WTA, Worden L, Blumberg S, Porco TC, Zipprich J

Clinical Infectious Diseases·2018
Mathematical Modeling

2017

2
Compartmental model diagrams as causal representations in relation to DAGs

Ackley SF, Mayeda ER, Worden L, Enanoria WTA, Glymour MM, Porco TC

Epidemiologic Methods·2017
Philosophy of ScienceMathematical ModelingResearch Credibility & Metascience
A dynamic model for estimating adult female mortality from ovarian dissection data for the tsetse fly Glossina pallidipes

Ackley SF, Hargrove JW

PLOS Neglected Tropical Diseases·2017
Mathematical Modeling

2015

1