Computational Epidemiology Lab
Featured Publications
A curated selection of recent and representative publications from the lab. Additional Publications
Evaluation of amyloid change as a surrogate for cognitive decline: demonstration in individual-level data from the A4 study of solanezumab
Ackley SF, Flanders MD, Murchland A, Chen R, Wang J, Shah SJ, Huey ED, Glymour MM
Alzheimer's & Dementia: Translational Research & Clinical Interventions·2026
Surrogate EvaluationDementia EpidemiologyDrugs and Devices
Trends in the distribution of P values in epidemiology journals: a statistical, P-curve, and simulation study
Ackley SF, Andrews RM, Seaman C, Flanders M, Chen R, Wang J, Lopes G, Sims KD, Buto P, Fer…
American Journal of Epidemiology·2025
Research Credibility & MetascienceMachine Learning and AIMathematical Modeling
Evaluating the presence of a physiologic ceiling in amyloid trajectories: insights from the Sampled Iterative Local Approximation (SILA) algorithm and simulations
Ackley SF, Gantenberg JR, Heston MB, La Joie R
Alzheimer's & Dementia (AAIC abstract)·2025
Surrogate EvaluationMathematical Modeling
Contribution of global amyloid-PET imaging for predicting future cognition in the MEMENTO cohort
Ackley SF, Calmasini C, Bouteloup V, Hill-Jarrett TG, Swinnerton KN, Chêne G, Dufouil C, G…
Neurology·2024
Surrogate EvaluationDementia EpidemiologyMachine Learning and AI
Estimated effects of amyloid reduction on cognitive change: a Bayesian update across a range of priors
Ackley SF, Wang J, Chen R, Power MC, Allen IE, Glymour MM
Alzheimer's & Dementia·2024
Surrogate EvaluationEvidence TriangulationDementia Epidemiology
Metformin cessation and dementia incidence
Zimmerman SC, Ferguson EL, Choudhary V, Ranatunga DK, Oni-Orisan A, Hayes-Larson E, Folle…
JAMA Network Open·2023
Drug RepurposingDementia EpidemiologyDrugs and Devices
Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis
Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER,…
BMJ·2021
Surrogate EvaluationEvidence TriangulationDrugs and Devices